In subcutaneous or intramuscular administration of interferon beta in serum levels determined for 12 24 hours after injection. The method of administration does not affect the level of interferon beta in serum. After a single dose injection of 60 mg maximum concentration defined by immunological methods is 3 hours after administration. At 4-fold subcutaneous administration of the same dose every 48 hr drug accumulation occurs moderately. After a single administration proviron steroid of the intracellular and serum activity of 2-5A synthetase and serum concentrations of beta 2 microglobulin and neopterin (markers of biological response) increased for 24 hours and then reduced for 2 days. Interferon beta is metabolized and excreted by the liver and kidneys.
Treatment of relapsing-remitting multiple sclerosis.
Efficacy has not been demonstrated in patients with secondary progressive multiple sclerosis in the absence of an active course of the disease (relapse).
- Hypersensitivity to natural or recombinant interferon beta, to other components of the preparation.
- Pregnancy and lactation (see. “Use during pregnancy and lactation”)
- Severe depressive disorders and / or suicidal ideation
- Epilepsy in the absence of the effect of the appropriate therapy.
- Age 12 years, because proviron steroid the effect of the drug in this age group have not been studied enough.
Dosing and Administration
The drug is administered subcutaneously.
Adults and adolescents over 16 years, the recommended dose of the drug is usually 44 mg 3 times a week. At a dose of 22 mg 3 times a week, Rebif ® is assigned to those patients who, in the opinion of the attending physician is not well tolerate high dose.
Adolescents from 12 years to 16 years, usually given dose of 22 mg 3 times a week. The drug should be used in one and the same time (preferably in the evening), on certain days, at intervals of not less than 48 hours.
Treatment is recommended to start under the supervision of a physician who is experienced in the treatment of this disease.
During the first 2 weeks of initiation of therapy proviron steroid be administered at a dose . For convenience, the corresponding syringe marked division. The remaining drug in the syringe is not subject to further use.
The decision on the duration of therapy should be taken individually by the attending physician. steroids for sale anabolisia steroideja netista