The drug has anti-viral, anti-tumor, immunomodulatory activity.
Recombinant human being in the drug active ingredient is synthesized bacterial cells of a strain, in the genetic apparatus which is integrated gene alpha-2b human interferon. It is a protein comprising 165 amino acids and is identical in characteristics and properties of human leukocyte interferon alpha-2b.
The antiviral action of interferon alpha-2b is shown during the reproduction of the virus by incorporating the active metabolic processes in cells. Interferon by interacting with specific receptors on cell surfaces initiates a series of intracellular changes that include the synthesis of specific cytokines and enzymes (2-5 adenilatsintetazy and protein), the action of which inhibits the formation of the viral protein and viral in the cell.
Immunomodulatory effects of alpha interferon -2b is to increase the phagocytic activity of macrophages, enhancing a specific cytotoxic action of lymphocytes to target cells, changing the qualitative and quantitative composition of secreted cytokines, change the functional activity of immune cells, production and secretion of changing intracellular proteins.
The antitumor effect of the drug is realized by suppressing the proliferation of tumor cells and the synthesis of some oncogenes, leading to inhibition of tumor growth.
The maximum concentration of interferon alfa-2b in the parenteral administration of the drug is observed within 2-4 hours. After 20-24 hours after administration of the recombinant alpha-2b interferon in serum is not determined. Interferon alfa-2b Serum is directly dependent on the dose of drug administered and the frequency of administration.
The metabolism in proviron side effects the liver, partly excreted unchanged, primarily via the kidneys.
In the treatment of adults:
– in acute viral hepatitis B – moderate and severe forms of the beginning of jaundice period until the 5th day of jaundice (at a later date the appointment of the drug is less effective, the drug is not effective in developing hepatic coma and cholestatic disease course);
– in acute protracted hepatitis B and C, chronic active hepatitis B and C, chronic hepatitis B with delta agent, with no signs of cirrhosis and signs of liver cirrhosis;
– if the kidney stage proviron side effectscancer, hairy cell leukemia, malignant skin lymphoma (mycosis fungoides, primary reticulosis, retikulosarkomatoze), Kaposi’s sarcoma, basal cell and squamous skin cancers, keratoacanthoma, chronic myeloid leukemia, histiocytosis of Langerhans cells subleukemic myelosis, essential thrombocythemia;
– for viral conjunctivitis, keratoconjunctivites, keratitis, keratoiridocyklites, keratouveitis; In complex therapy children from 1 year: – acute lymphoblastic leukemia in remission after induction chemotherapy (4-5 month remission); – for respiratory papillomatosis of the larynx, starting from the day after the removal of warts.