Often by parenteral administration of the drug bayer proviron is observed flu-like symptoms (chills, fever, asthenia, fatigue, fatigue, myalgia, arthralgia, headache), partially cropped paracetamol, indomethacin. Typically, flu syndrome manifests itself at the beginning of treatment and decreases with continued.
Since the cardiovascular system: rarely – arrhythmias, transient reversible cardiomyopathy, very rarely – hypotension, myocardial infarction. From the digestive system: rarely – dry mouth, nausea , abdominal pain, dyspepsia, disorders of appetite, weight loss, vomiting, diarrhea, rarely – pancreatitis, hepatotoxicity. On the part of the central nervous system: rarely – irritability, nervousness, depression, fatigue, insomnia, anxiety, impaired ability to concentrate , suicidal thoughts, aggressiveness, very rarely – neuropathy, psychosis.For the skin: rare – skin rash and itching, increased sweating, loss of hair. When injected into the hearth or under the lesion is rarely a local inflammatory response. These side effects usually are not an obstacle for the continuation of the drug. On the part of the endocrine system: on the background of long-term use of the drug may be changes in the thyroid gland. Very bayer proviron seldom – diabetes. From the laboratory parameters: the application of the drug may abnormal laboratory values, manifested leukopenia, lymphopenia, thrombocytopenia, anemia, increased activity of alanine aminotransferase, alkaline phosphatase, creatinine concentration, urea. As a rule, these changes tend to be minor , asymptomatic and reversible.
On the part of the musculoskeletal system: rarely – rhabdomyolysis, leg cramps, back pain, myositis, myalgia. The respiratory system: rarely – sore throat, cough, dyspnea, pneumonia. From the mochevydelitelnoy system: very rarely – renal failure. immune system: seldom – an autoimmune pathology (vasculitis, rheumatoid arthritis, lupus-like syndrome), very rarely – sarcoidosis, angioneurotic allergic edema, anaphylaxis, swelling of the face. From the side of view: the local application of the drug on the mucous membrane of the eye possible congestion, individual follicles, swelling of the conjunctiva of the lower arch. Rarely – retinal hemorrhages, focal changes in the fundus, thrombosis of arteries and veins of the retina, decreased visual acuity, optic neuritis, papilledema. From the hearing: rarely – hearing loss. At sharply expressed by local and systemic adverse reactions to the introduction bayer proviron of the drug should be discontinued.
No cases of overdose were observed. Given that the active substance is interferon alfa-2b, then an overdose may increase the severity of dose-dependent side effects. Treatment: removal of the drug; if necessary spend symptomatic therapy.